the chronic and acute effect of submaximal pedaling activity along with blood flow restriction on serum bdnf and tnf-α in active men

this study aimed at determining the chronic and acute effect of submaximal pedaling activity along with blood flow restriction on serum bdnf, tnf-α and bdnf/tnf-α ratio in active men. 24 physical education students at kharazmi university volunteered for the study. they were divided into three groups: pedaling with lower extremity vascular occlusion (n=8), pedaling without occlusion (n=8), and control (n=8). subjects in the occlusion and non-occlusion groups exercised for 3 weeks, 3 sessions per week (9 sessions totally). each session included three 3-min. phases of pedaling at 50% of maximum power (wmax) with 30–45 s rest interval between each two phases. the pressure on the thigh in the occlusion group was 140–170 mmhg. to analyze the data, one-way analysis of variance and independent and dependent t tests were used. results showed that leg vessels occlusion during submaximal pedaling had no significant differences on response of bdnf (p=0.290)، tnf-α (p=0.338) and their ratio (p=0.384) compared with the non-occlusion group. in addition, in the compatibility phase, there were no significant differences in bdnf (p=0.254)، tnf-α (p=0.338) and their ratio (p=0.384) among occlusion, non-occlusion and control groups. results showed that local blood flow restriction had no positive or negative effects on the amounts of bdnf, tnf-α and their ratio.